Pesquisa | BVS IEC

1.

Tau interactome maps synaptic and mitochondrial processes associated with neurodegeneration.

Tracy, Tara E; Madero-Pérez, Jesus; Swaney, Danielle L; Chang, Timothy S; Moritz, Michelle; Konrad, Csaba; Ward, Michael E; Stevenson, Erica; Hüttenhain, Ruth; Kauwe, Grant; Mercedes, Maria; Sweetland-Martin, Lauren; Chen, Xu; Mok, Sue-Ann; Wong, Man Ying; Telpoukhovskaia, Maria; Min, Sang-Won; Wang, Chao; Sohn, Peter Dongmin; Martin, Jordie; Zhou, Yungui; Luo, Wenjie; Trojanowski, John Q; Lee, Virginia M Y; Gong, Shiaoching; Manfredi, Giovanni; Coppola, Giovanni; Krogan, Nevan J; Geschwind, Daniel H; Gan, Li.

Cell ; 185(4): 712-728.e14, 2022 02 17.

Artigo em Inglês | MEDLINE | ID: mdl-35063084

2.

A blood atlas of COVID-19 defines hallmarks of disease severity and specificity.

Cell ; 185(5): 916-938.e58, 2022 03 03.

Artigo em Inglês | MEDLINE | ID: mdl-35216673

3.

COVID-19 and the human innate immune system.

Schultze, Joachim L; Aschenbrenner, Anna C.

Cell ; 184(7): 1671-1692, 2021 04 01.

Artigo em Inglês | MEDLINE | ID: mdl-33743212

4.

Enteric helminth coinfection enhances host susceptibility to neurotropic flaviviruses via a tuft cell-IL-4 receptor signaling axis.

Desai, Pritesh; Janova, Hana; White, James P; Reynoso, Glennys V; Hickman, Heather D; Baldridge, Megan T; Urban, Joseph F; Stappenbeck, Thaddeus S; Thackray, Larissa B; Diamond, Michael S.

Cell ; 184(5): 1214-1231.e16, 2021 03 04.

Artigo em Inglês | MEDLINE | ID: mdl-33636133

5.

Maturation and persistence of the anti-SARS-CoV-2 memory B cell response.

Sokal, Aurélien; Chappert, Pascal; Barba-Spaeth, Giovanna; Roeser, Anais; Fourati, Slim; Azzaoui, Imane; Vandenberghe, Alexis; Fernandez, Ignacio; Meola, Annalisa; Bouvier-Alias, Magali; Crickx, Etienne; Beldi-Ferchiou, Asma; Hue, Sophie; Languille, Laetitia; Michel, Marc; Baloul, Samia; Noizat-Pirenne, France; Luka, Marine; Mégret, Jérôme; Ménager, Mickaël; Pawlotsky, Jean-Michel; Fillatreau, Simon; Rey, Felix A; Weill, Jean-Claude; Reynaud, Claude-Agnès; Mahévas, Matthieu.

Cell ; 184(5): 1201-1213.e14, 2021 03 04.

Artigo em Inglês | MEDLINE | ID: mdl-33571429

6.

Time-resolved systems immunology reveals a late juncture linked to fatal COVID-19.

Liu, Can; Martins, Andrew J; Lau, William W; Rachmaninoff, Nicholas; Chen, Jinguo; Imberti, Luisa; Mostaghimi, Darius; Fink, Danielle L; Burbelo, Peter D; Dobbs, Kerry; Delmonte, Ottavia M; Bansal, Neha; Failla, Laura; Sottini, Alessandra; Quiros-Roldan, Eugenia; Han, Kyu Lee; Sellers, Brian A; Cheung, Foo; Sparks, Rachel; Chun, Tae-Wook; Moir, Susan; Lionakis, Michail S; Rossi, Camillo; Su, Helen C; Kuhns, Douglas B; Cohen, Jeffrey I; Notarangelo, Luigi D; Tsang, John S.

Cell ; 184(7): 1836-1857.e22, 2021 04 01.

Artigo em Inglês | MEDLINE | ID: mdl-33713619

7.

The interferon landscape along the respiratory tract impacts the severity of COVID-19.

Sposito, Benedetta; Broggi, Achille; Pandolfi, Laura; Crotta, Stefania; Clementi, Nicola; Ferrarese, Roberto; Sisti, Sofia; Criscuolo, Elena; Spreafico, Roberto; Long, Jaclyn M; Ambrosi, Alessandro; Liu, Enju; Frangipane, Vanessa; Saracino, Laura; Bozzini, Sara; Marongiu, Laura; Facchini, Fabio A; Bottazzi, Andrea; Fossali, Tommaso; Colombo, Riccardo; Clementi, Massimo; Tagliabue, Elena; Chou, Janet; Pontiroli, Antonio E; Meloni, Federica; Wack, Andreas; Mancini, Nicasio; Zanoni, Ivan.

Cell ; 184(19): 4953-4968.e16, 2021 09 16.

Artigo em Inglês | MEDLINE | ID: mdl-34492226

8.

Impaired local intrinsic immunity to SARS-CoV-2 infection in severe COVID-19.

Ziegler, Carly G K; Miao, Vincent N; Owings, Anna H; Navia, Andrew W; Tang, Ying; Bromley, Joshua D; Lotfy, Peter; Sloan, Meredith; Laird, Hannah; Williams, Haley B; George, Micayla; Drake, Riley S; Christian, Taylor; Parker, Adam; Sindel, Campbell B; Burger, Molly W; Pride, Yilianys; Hasan, Mohammad; Abraham, George E; Senitko, Michal; Robinson, Tanya O; Shalek, Alex K; Glover, Sarah C; Horwitz, Bruce H; Ordovas-Montanes, Jose.

Cell ; 184(18): 4713-4733.e22, 2021 09 02.

Artigo em Inglês | MEDLINE | ID: mdl-34352228

9.

Functional SARS-CoV-2-Specific Immune Memory Persists after Mild COVID-19.

Rodda, Lauren B; Netland, Jason; Shehata, Laila; Pruner, Kurt B; Morawski, Peter A; Thouvenel, Christopher D; Takehara, Kennidy K; Eggenberger, Julie; Hemann, Emily A; Waterman, Hayley R; Fahning, Mitchell L; Chen, Yu; Hale, Malika; Rathe, Jennifer; Stokes, Caleb; Wrenn, Samuel; Fiala, Brooke; Carter, Lauren; Hamerman, Jessica A; King, Neil P; Gale, Michael; Campbell, Daniel J; Rawlings, David J; Pepper, Marion.

Cell ; 184(1): 169-183.e17, 2021 01 07.

Artigo em Inglês | MEDLINE | ID: mdl-33296701

10.

COVID-19-neutralizing antibodies predict disease severity and survival.

Garcia-Beltran, Wilfredo F; Lam, Evan C; Astudillo, Michael G; Yang, Diane; Miller, Tyler E; Feldman, Jared; Hauser, Blake M; Caradonna, Timothy M; Clayton, Kiera L; Nitido, Adam D; Murali, Mandakolathur R; Alter, Galit; Charles, Richelle C; Dighe, Anand; Branda, John A; Lennerz, Jochen K; Lingwood, Daniel; Schmidt, Aaron G; Iafrate, A John; Balazs, Alejandro B.

Cell ; 184(2): 476-488.e11, 2021 01 21.

Artigo em Inglês | MEDLINE | ID: mdl-33412089

11.

Baricitinib treatment resolves lower-airway macrophage inflammation and neutrophil recruitment in SARS-CoV-2-infected rhesus macaques.

Hoang, Timothy N; Pino, Maria; Boddapati, Arun K; Viox, Elise G; Starke, Carly E; Upadhyay, Amit A; Gumber, Sanjeev; Nekorchuk, Michael; Busman-Sahay, Kathleen; Strongin, Zachary; Harper, Justin L; Tharp, Gregory K; Pellegrini, Kathryn L; Kirejczyk, Shannon; Zandi, Keivan; Tao, Sijia; Horton, Tristan R; Beagle, Elizabeth N; Mahar, Ernestine A; Lee, Michelle Y H; Cohen, Joyce; Jean, Sherrie M; Wood, Jennifer S; Connor-Stroud, Fawn; Stammen, Rachelle L; Delmas, Olivia M; Wang, Shelly; Cooney, Kimberly A; Sayegh, Michael N; Wang, Lanfang; Filev, Peter D; Weiskopf, Daniela; Silvestri, Guido; Waggoner, Jesse; Piantadosi, Anne; Kasturi, Sudhir P; Al-Shakhshir, Hilmi; Ribeiro, Susan P; Sekaly, Rafick P; Levit, Rebecca D; Estes, Jacob D; Vanderford, Thomas H; Schinazi, Raymond F; Bosinger, Steven E; Paiardini, Mirko.

Cell ; 184(2): 460-475.e21, 2021 01 21.

Artigo em Inglês | MEDLINE | ID: mdl-33278358

12.

Proteomic and Metabolomic Characterization of COVID-19 Patient Sera.

Shen, Bo; Yi, Xiao; Sun, Yaoting; Bi, Xiaojie; Du, Juping; Zhang, Chao; Quan, Sheng; Zhang, Fangfei; Sun, Rui; Qian, Liujia; Ge, Weigang; Liu, Wei; Liang, Shuang; Chen, Hao; Zhang, Ying; Li, Jun; Xu, Jiaqin; He, Zebao; Chen, Baofu; Wang, Jing; Yan, Haixi; Zheng, Yufen; Wang, Donglian; Zhu, Jiansheng; Kong, Ziqing; Kang, Zhouyang; Liang, Xiao; Ding, Xuan; Ruan, Guan; Xiang, Nan; Cai, Xue; Gao, Huanhuan; Li, Lu; Li, Sainan; Xiao, Qi; Lu, Tian; Zhu, Yi; Liu, Huafen; Chen, Haixiao; Guo, Tiannan.

Cell ; 182(1): 59-72.e15, 2020 07 09.

Artigo em Inglês | MEDLINE | ID: mdl-32492406

13.

A Mouse-Adapted SARS-CoV-2 Induces Acute Lung Injury and Mortality in Standard Laboratory Mice.

Leist, Sarah R; Dinnon, Kenneth H; Schäfer, Alexandra; Tse, Longping V; Okuda, Kenichi; Hou, Yixuan J; West, Ande; Edwards, Caitlin E; Sanders, Wes; Fritch, Ethan J; Gully, Kendra L; Scobey, Trevor; Brown, Ariane J; Sheahan, Timothy P; Moorman, Nathaniel J; Boucher, Richard C; Gralinski, Lisa E; Montgomery, Stephanie A; Baric, Ralph S.

Cell ; 183(4): 1070-1085.e12, 2020 11 12.

Artigo em Inglês | MEDLINE | ID: mdl-33031744

14.

The Immunology of Multisystem Inflammatory Syndrome in Children with COVID-19.

Consiglio, Camila Rosat; Cotugno, Nicola; Sardh, Fabian; Pou, Christian; Amodio, Donato; Rodriguez, Lucie; Tan, Ziyang; Zicari, Sonia; Ruggiero, Alessandra; Pascucci, Giuseppe Rubens; Santilli, Veronica; Campbell, Tessa; Bryceson, Yenan; Eriksson, Daniel; Wang, Jun; Marchesi, Alessandra; Lakshmikanth, Tadepally; Campana, Andrea; Villani, Alberto; Rossi, Paolo; Landegren, Nils; Palma, Paolo; Brodin, Petter.

Cell ; 183(4): 968-981.e7, 2020 11 12.

Artigo em Inglês | MEDLINE | ID: mdl-32966765

15.

Multi-Omics Resolves a Sharp Disease-State Shift between Mild and Moderate COVID-19.

Su, Yapeng; Chen, Daniel; Yuan, Dan; Lausted, Christopher; Choi, Jongchan; Dai, Chengzhen L; Voillet, Valentin; Duvvuri, Venkata R; Scherler, Kelsey; Troisch, Pamela; Baloni, Priyanka; Qin, Guangrong; Smith, Brett; Kornilov, Sergey A; Rostomily, Clifford; Xu, Alex; Li, Jing; Dong, Shen; Rothchild, Alissa; Zhou, Jing; Murray, Kim; Edmark, Rick; Hong, Sunga; Heath, John E; Earls, John; Zhang, Rongyu; Xie, Jingyi; Li, Sarah; Roper, Ryan; Jones, Lesley; Zhou, Yong; Rowen, Lee; Liu, Rachel; Mackay, Sean; O'Mahony, D Shane; Dale, Christopher R; Wallick, Julie A; Algren, Heather A; Zager, Michael A; Wei, Wei; Price, Nathan D; Huang, Sui; Subramanian, Naeha; Wang, Kai; Magis, Andrew T; Hadlock, Jenn J; Hood, Leroy; Aderem, Alan; Bluestone, Jeffrey A; Lanier, Lewis L.

Cell ; 183(6): 1479-1495.e20, 2020 12 10.

Artigo em Inglês | MEDLINE | ID: mdl-33171100

16.

Tracking Changes in SARS-CoV-2 Spike: Evidence that D614G Increases Infectivity of the COVID-19 Virus.

Korber, Bette; Fischer, Will M; Gnanakaran, Sandrasegaram; Yoon, Hyejin; Theiler, James; Abfalterer, Werner; Hengartner, Nick; Giorgi, Elena E; Bhattacharya, Tanmoy; Foley, Brian; Hastie, Kathryn M; Parker, Matthew D; Partridge, David G; Evans, Cariad M; Freeman, Timothy M; de Silva, Thushan I; McDanal, Charlene; Perez, Lautaro G; Tang, Haili; Moon-Walker, Alex; Whelan, Sean P; LaBranche, Celia C; Saphire, Erica O; Montefiori, David C.

Cell ; 182(4): 812-827.e19, 2020 08 20.

Artigo em Inglês | MEDLINE | ID: mdl-32697968

17.

Host-Viral Infection Maps Reveal Signatures of Severe COVID-19 Patients.

Bost, Pierre; Giladi, Amir; Liu, Yang; Bendjelal, Yanis; Xu, Gang; David, Eyal; Blecher-Gonen, Ronnie; Cohen, Merav; Medaglia, Chiara; Li, Hanjie; Deczkowska, Aleksandra; Zhang, Shuye; Schwikowski, Benno; Zhang, Zheng; Amit, Ido.

Cell ; 181(7): 1475-1488.e12, 2020 06 25.

Artigo em Inglês | MEDLINE | ID: mdl-32479746

18.

Imbalance of Regulatory and Cytotoxic SARS-CoV-2-Reactive CD4⁺ T Cells in COVID-19.

Meckiff, Benjamin J; Ramírez-Suástegui, Ciro; Fajardo, Vicente; Chee, Serena J; Kusnadi, Anthony; Simon, Hayley; Eschweiler, Simon; Grifoni, Alba; Pelosi, Emanuela; Weiskopf, Daniela; Sette, Alessandro; Ay, Ferhat; Seumois, Grégory; Ottensmeier, Christian H; Vijayanand, Pandurangan.

Cell ; 183(5): 1340-1353.e16, 2020 11 25.

Artigo em Inglês | MEDLINE | ID: mdl-33096020

19.

Antigen-Specific Adaptive Immunity to SARS-CoV-2 in Acute COVID-19 and Associations with Age and Disease Severity.

Rydyznski Moderbacher, Carolyn; Ramirez, Sydney I; Dan, Jennifer M; Grifoni, Alba; Hastie, Kathryn M; Weiskopf, Daniela; Belanger, Simon; Abbott, Robert K; Kim, Christina; Choi, Jinyong; Kato, Yu; Crotty, Eleanor G; Kim, Cheryl; Rawlings, Stephen A; Mateus, Jose; Tse, Long Ping Victor; Frazier, April; Baric, Ralph; Peters, Bjoern; Greenbaum, Jason; Ollmann Saphire, Erica; Smith, Davey M; Sette, Alessandro; Crotty, Shane.

Cell ; 183(4): 996-1012.e19, 2020 11 12.

Artigo em Inglês | MEDLINE | ID: mdl-33010815

20.

An immunodominant NP_105-113-B*07:02 cytotoxic T cell response controls viral replication and is associated with less severe COVID-19 disease.

Peng, Yanchun; Felce, Suet Ling; Dong, Danning; Penkava, Frank; Mentzer, Alexander J; Yao, Xuan; Liu, Guihai; Yin, Zixi; Chen, Ji-Li; Lu, Yongxu; Wellington, Dannielle; Wing, Peter A C; Dominey-Foy, Delaney C C; Jin, Chen; Wang, Wenbo; Hamid, Megat Abd; Fernandes, Ricardo A; Wang, Beibei; Fries, Anastasia; Zhuang, Xiaodong; Ashley, Neil; Rostron, Timothy; Waugh, Craig; Sopp, Paul; Hublitz, Philip; Beveridge, Ryan; Tan, Tiong Kit; Dold, Christina; Kwok, Andrew J; Rich-Griffin, Charlotte; Dejnirattisa, Wanwisa; Liu, Chang; Kurupati, Prathiba; Nassiri, Isar; Watson, Robert A; Tong, Orion; Taylor, Chelsea A; Kumar Sharma, Piyush; Sun, Bo; Curion, Fabiola; Revale, Santiago; Garner, Lucy C; Jansen, Kathrin; Ferreira, Ricardo C; Attar, Moustafa; Fry, Jeremy W; Russell, Rebecca A; Stauss, Hans J; James, William; Townsend, Alain.

Nat Immunol ; 23(1): 50-61, 2022 01.

Artigo em Inglês | MEDLINE | ID: mdl-34853448

BVS IEC

Instituto Evandro Chagas

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